代谢组学在肿瘤药物靶点筛选中的应用进展

肿瘤是一种多因素参与造成机体各系统功能平衡紊乱的代谢性疾病,代谢重编程是恶性肿瘤的重要特征之一.研究"代谢指纹图谱"的代谢组学,通过揭示肿瘤或药物引起的宿主内源性代谢物的变化,为肿瘤药物靶点的筛选提供了可能.但目前对代谢组在肿瘤药物靶点筛选中的整体性综述并不多见,因此,本文在介绍了代谢组学筛选肿瘤药物靶点的流程的基础上...

Application Progress of Metabolomics in Tumor Drug Target Screening

Tumor is a metabolic disease that is involved in various factors and causes the disorder of the function balance of various systems of the body.Metabolic reprogramming is an important sign of malignant tumor.Metabolomics of studying “metabolic fingerprint” can be used to mine the key metabolites related to tumor and their metabolic reprogramming pathways,and is widely used in the screening of tumor target drugs.However,there are few overall reviews on metabonomics in tumor drug target screening.This paper firstly introduces the process of metabolomics screening tumor drug targets,then elaborates the metabolomics in the screening of tumor drug targets in the fields of glucose metabolism,amino acid metabolism,lipid metabolism and other fields,revealing tumor drug-resistant mechanism,and in the application of screening target drugs.Finally the paper discusses the existing issues and future development trend of metabolomics in the research of tumor drug targets,aiming to provide reference and scientific basis for further studying and understanding the important role of metabolomics in tumor pathogenesis and drug target uncovering.