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CKLF1作为缺血性脑卒中治疗的潜在靶点
引用本文:谌浩东,刘杨波,宁娜,冯聚玲,艾启迪,杨岩涛,贺文彬,楚世峰,陈乃宏. CKLF1作为缺血性脑卒中治疗的潜在靶点[J]. 生物化学与生物物理进展, 2022, 0(1): 126-138
作者姓名:谌浩东  刘杨波  宁娜  冯聚玲  艾启迪  杨岩涛  贺文彬  楚世峰  陈乃宏
作者单位:湖南中医药大学药学院;山西中医药大学;中国医学科学院;国家药品监督管理局药品审评中心
基金项目:国家自然科学基金(81873026,82074044,81730096);北京市自然科学基金(7192135);山西省重点研发计划(201803D421006);中国医学科学院医学与健康科技创新工程(2016-I2M-1-004)资助项目。
摘    要:缺血性脑卒中是一种血液循环障碍疾病,可导致严重的神经功能缺损.卒中病人中约有87%的病例为缺血性卒中.神经炎症是中风损伤的主要病理状态之一.CKLF1是2001年发现的非经典CC型趋化因子,对单核细胞、中性粒细胞和淋巴细胞表现出很强的趋化活性.CKLF1在胎儿大脑中含量最高,但在健康成人阶段不存在.越来越多的证据表明,...

关 键 词:趋化素样因子1  缺血性脑卒中  趋化性  小胶质细胞  中性粒细胞  炎症  抑制剂

CKLF1 as a Potential Therapeutic Target for Ischemic Stroke
CHEN Hao-Dong,LIU Yang-Bo,NING Na,FENG Ju-Ling,AI Qi-Di,YANG Yan-Tao,HE Wen-Bin,CHU Shi-Feng,CHEN Nai-Hong. CKLF1 as a Potential Therapeutic Target for Ischemic Stroke[J]. Progress In Biochemistry and Biophysics, 2022, 0(1): 126-138
Authors:CHEN Hao-Dong  LIU Yang-Bo  NING Na  FENG Ju-Ling  AI Qi-Di  YANG Yan-Tao  HE Wen-Bin  CHU Shi-Feng  CHEN Nai-Hong
Affiliation:(Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces&College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Shanxi Key Laboratory of Chinese Medicine Encephalopathy,Shanxi University of Chinese Medicine,Taiyuan 030024,China;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medica&Neuroscience Center,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;Center for Drug Evaluation,China National Medical Products Administration,Beijing 100022,China)
Abstract:Ischemic stroke is a kind of stroke in which the blood supply to the brain is disrupted,resulting in serious neurological deficits.Among stroke patients,about 87%of the cases are ischemic stroke.Neuroinflammation is one of the main pathological conditions of stroke injury.CKLF1 is a non-classical CC-type chemokine discovered in 2001,which showed strong chemotactic activity on monocytes,neutrophils,and lymphocytes.CKLF1 is most abundant in the fetal brain,but absent in the healthy adult.Growing evidence shows that CKLF1 is reactivated and expressed in adult stroke animal models and participates in multiple processing of neuroinflammatory responses.CKLF1 could activate the polarization of microglia to produce inflammatory mediators and trigger inflammation in the injured brain.And then they drove peripheral immune cells such as neutrophils to recruit into the injured brain.These stimulated the greater immune responses and destroyed the fragile blood-brain barrier(BBB).We believe that CKLF1 plays an important role in the course of ischemic stroke.However,the development of its biological activity and drug discovery lacks systematic literature reports.Thus,we collected the published data and made this review,to briefly describe the role of CKLF1 in ischemic stroke,and explained its mechanism of aggravating ischemic stroke.Moreover,some potential anti-stroke drugs have been discovered,indicating that CKLF1 is a potential target for the treatment of ischemic stroke.
Keywords:CKLF1  ischemic stroke  chemotaxis  microglia  neutrophil  inflammation  inhibitor
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