| HSP27对细胞迁移的调控 |
| |
| 引用本文： | 张宝宏,谢飞,任海军,刘波.HSP27对细胞迁移的调控[J].生物化学与生物物理进展,2017,44(2):110-116. |
| |
| 作者姓名： | 张宝宏 谢飞 任海军 刘波 |
| |
| 作者单位： | 大连理工大学生物医学工程系,大连理工大学生物医学工程系,大连市友谊医院普外科,大连理工大学生物医学工程系 |
| |
| 基金项目： | 国家自然科学基金（No. 31670867）, 大连市卫生局医学研究课题（WSJ/KJC-01-JL-01） |
| |
| 摘 要： | 细胞迁移是多细胞生物的一项基本生理过程,不仅在血管重建、炎症反应、发育、伤口愈合等方面发挥重要作用,而且还与肿瘤细胞侵袭和转移有关.热休克蛋白27(heat shock protein27,HSP27)是小型热休克蛋白家族中研究最广泛的成员之一,普遍存在于生物体内.HSP27是一种多功能蛋白质,可以通过黏着斑和肌动蛋白调节细胞迁移.另外,HSP27还可调控肿瘤早期的上皮间质转化,影响癌症转移.本文整理了近期关于HSP27参与细胞迁移及相应的肿瘤细胞转移方面的研究,探究HSP27在临床医学研究领域的价值和应用前景.
|
| 关 键 词： | 热休克蛋白27 细胞迁移 肿瘤细胞转移 |
| 收稿时间： | 2016/9/10 0:00:00 |
| 修稿时间： | 2016/12/26 0:00:00 |
Regulation of HSP27 on Cell Migration |
| |
| ZHANG Bao-Hong,XIE Fei,REN Hai-Jun and LIU Bo.Regulation of HSP27 on Cell Migration[J].Progress In Biochemistry and Biophysics,2017,44(2):110-116. |
| |
| Authors: | ZHANG Bao-Hong XIE Fei REN Hai-Jun and LIU Bo |
| |
| Institution: | Department of Biomedical Engineering, Dalian University of Technology,Department of Biomedical Engineering, Dalian University of Technology,Department of General Surgery, Dalian Friendship Hospital,Department of Biomedical Engineering, Dalian University of Technology |
| |
| Abstract: | Cell migration is an essential progress in multicellular organisms. It is critical for many processes, such as angiogenesis, inflammation, development and wound healing. Besides, cell migration is also involved invasion and metastasis of tumor cells. The heat shock protein 27(HSP27) is one of the most widely studied members of small heat shock protein family, which is ubiquitous in organisms. HSP27 is a multifunctional protein, which is involved in cell migration process by regulating focal adhesion and actin polymerization. In addition, HSP27 could also regulate epithelial mesenchymal transition in the early phase of tumor progression and metastasis. This review focuses on the recent researches about the role of HSP27 in cell migration and tumor metastasis, and also suggests the potential value of HSP27 in clinical treatment. |
| |
| Keywords: | HSP27 cell migration tumor metastasis |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《生物化学与生物物理进展》浏览原始摘要信息 |
| 点击此处可从《生物化学与生物物理进展》下载免费的PDF全文 |
|
