Heme oxygenase-1 comes back to endoplasmic reticulum |
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| Authors: | Hong Pyo Kim Hyun-Ock Pae Sung Hun Back Su Wol Chung Je Moon Woo Yong Son Hun-Taeg Chung |
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| Affiliation: | aSchool of Biological Sciences, Ulsan University, Republic of Korea;bDepartment of Immunology, Wonkwang University School of Medicine, Republic of Korea;cDepartment of Opthalmology, Ulasn University Hospital, Republic of Korea;dDepartment of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, Republic of Korea |
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| Abstract: | Originally identified as a rate-limiting enzyme for heme catabolism, heme oxygenase-1 (HO-1) has expanded its roles in anti-inflammation, anti-apoptosis and anti-proliferation for the last decade. Regulation of protein activity by location is well appreciated. Even though multiple compartmentalization of HO-1 has been documented, the functional implication of this enzyme at these subcellular organelles is only partially elucidated. In this review we discuss the endoplasmic reticulum (ER)-residing HO-1 and its cytoprotective activity against ER stress. |
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| Keywords: | Heme oxygenase Endoplasmic reticulum Unfolded protein response Carbon monoxide |
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