Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor,artemisinic acid |
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| Authors: | Dae-Kyun Ro Mario Ouellet Eric M Paradise Helcio Burd Diana Eng Chris J Paddon Jack D Newman " target="_blank">Jay D Keasling |
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| Institution: | (1) Department of Biological Sciences, University of Calgary, Calgary, T2N 1N4, Canada;(2) California Institute of Quantitative Biomedical Research, University of California, Berkeley, USA;(3) Department of Chemical Engineering, University of California, Berkeley, 94720, USA;(4) Amyris Biotechnologies, Emeryville, USA;(5) Department of Bioengineering, University of California, Berkeley, USA;(6) Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, USA |
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| Abstract: | Background Due to the global occurrence of multi-drug-resistant malarial parasites (Plasmodium falciparum), the anti-malarial drug most effective against malaria is artemisinin, a natural product (sesquiterpene lactone endoperoxide)
extracted from sweet wormwood (Artemisia annua). However, artemisinin is in short supply and unaffordable to most malaria patients. Artemisinin can be semi-synthesized
from its precursor artemisinic acid, which can be synthesized from simple sugars using microorganisms genetically engineered
with genes from A. annua. In order to develop an industrially competent yeast strain, detailed analyses of microbial physiology and development of
gene expression strategies are required. |
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