Isoforms of apolipoprotein C-I associated with individuals with coronary artery disease |
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| Authors: | Moore D'Vesharronne McNeal Catherine Macfarlane Ronald |
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| Institution: | aLaboratory for Cardiovascular Chemistry, Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA;bDepartment of Internal Medicine, Scott & White Healthcare, Temple, TX 77801, USA |
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| Abstract: | Apolipoprotein C-I (apoC-I) is a 6.6 kDa serum protein associated with high density lipoproteins (HDL) and triglyceride-rich lipoproteins. In this study, apoC-I was examined in high density lipoprotein subfractions from individuals with and without coronary artery disease (CAD). New isoforms of apoC-I, were detected in the cohort of individuals with CAD using mass spectrometry while the expected apoC-I isoforms were absent. In addition, the apoC-I mass spectra for the CAD cohort had satellite peaks indicative of the involvement of oxidative processes. Further analysis of the mass spectra of the CAD and non-CAD cohorts suggest that the origin of these new isoforms may be due to genetic mutations that could compromise the function of apoC-I. |
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| Keywords: | HDL Apolipoprotein C-I Isoforms MALDI Atherogenic HDL |
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