Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway |
| |
| Authors: | Marco J Koudijs Marjo J den Broeder Evelyn Groot Fredericus JM van Eeden |
| |
| Affiliation: | (1) Developmental Biology and Stem Cell Research, Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands;(2) Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK |
| |
| Abstract: | Background Aberrant activation of the Hedgehog (Hh) signaling pathway in different organisms has shown the importance of this family of morphogens during development. Genetic screens in zebrafish have assigned specific roles for Hh in proliferation, differentiation and patterning, but mainly as a result of a loss of its activity. We attempted to fully activate the Hh pathway by removing both receptors for the Hh proteins, called Patched1 and 2, which are functioning as negative regulators in this pathway. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
