Interrelationships between mitochondrial fusion, energy metabolism and oxidative stress during development in Caenorhabditis elegans |
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Authors: | Yasuda Kayo Hartman Philip S Ishii Takamasa Suda Hitoshi Akatsuka Akira Shoyama Tetsuji Miyazawa Masaki Ishii Naoaki |
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Institution: | aDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan;bEducation and Research Support Center, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan;cBiology Department, Texas Christian University, Fort Worth, TX 76129, USA;dSchool of High-Technology for Human Welfare, Tokai University, Nishino 317, Numazu, Shizuoka 410-0395, Japan |
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Abstract: | Mitochondria are known to be dynamic structures with the energetically and enzymatically mediated processes of fusion and fission responsible for maintaining a constant flux. Mitochondria also play a role of reactive oxygen species production as a byproduct of energy metabolism. In the current study, interrelationships between mitochondrial fusion, energy metabolism and oxidative stress on development were explored using a fzo-1 mutant defective in the fusion process and a mev-1 mutant overproducing superoxide from mitochondrial electron transport complex II of Caenorhabditis elegans. While growth and development of both single mutants was slightly delayed relative to the wild type, the fzo-1;mev-1 double mutant experienced considerable delay. Oxygen sensitivity during larval development, superoxide production and carbonyl protein accumulation of the fzo-1 mutant were similar to wild type. fzo-1 animals had significantly lower metabolism than did N2 and mev-1. These data indicate that mitochondrial fusion can profoundly affect energy metabolism and development. |
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Keywords: | Mitochondrial fusion Oxidative stress Development Energy metabolism fzo-1 |
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