Repair of corneal defects using tissue engineering

We propose to treat deep corneal burns by grafting a living stromal equivalent, since keratocyte death and stromal destruction are the main factors of ulceration and destruction of the eye. A technique was developed for isolation and grafting a living stroma equivalent. Twenty one patients with deep corneal defects were treated. A stable therapeutic effect was observed in 95% cases. The advantage of the developed method is a partial recovery of affected corneal transparency.Translated from Izvestiya Akademii Nauk, Seriya Biologicheskaya, No. 1, 2005, pp. 5–8.Original Russian Text Copyright © 2005 by Vasiliev, Makarov, Rogovaya, Gundorova, Terskikh