Localization of VIP-immunoreactive nerves in airways and pulmonary vessels of dogs,cats, and human subjects |
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| Authors: | Dr. Richard D. Dey W. Allen Shannon Jr. Sami I. Said |
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| Affiliation: | (1) Veterans Administration Medical Center, Dallas, Texas;(2) Departments of Cell Biology, Internal Medicine, and Pharmacology, University of Texas Health Science Center, Dallas, Texas, USA;(3) Department of Cell Biology, University of Texas Health Science Center at Dallas, 5323 Harry Hines Boulevard, 75235 Dallas, Texas, USA |
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| Abstract: | Summary VIP-containing neurons were localized in lungs from dogs, cats, and human subjects by means of the indirect immunofluorescence technique. Nerve fibers and terminals were observed in the smooth muscle layer and glands of airways, and within the walls of pulmonary and bronchial vessels, especially at the medial-adventitial junction. VIP-positive nerve cell bodies were identified in ganglia located in the walls of bronchi. These findings provide an anatomic basis for the possible modulation of airway and pulmonary vascular function by this neuropeptide.Supported by National Research Service Award HL 5914 and by Lung Center Award HL 14187 from NHLBI, USPHS |
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| Keywords: | Vasoactive intestinal peptide (VIP) Peptidergic nerves Pulmonary innervation |
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