| 红细胞抗高血压因子舒血管作用机制的研究 |
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| 引用本文： | 路涛,文允镒.红细胞抗高血压因子舒血管作用机制的研究[J].中国应用生理学杂志,1994,10(1):5-8. |
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| 作者姓名： | 路涛 文允镒 |
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| 作者单位： | 中国医学科学院基础医学研究所 |
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| 摘 要： | 本实验研究了从Ｓｐｒａｇｕｅ－Ｄａｗｌｅｙ大鼠红细胞中提取的抗高血压因子（ａｎｔｉｈｙｐｅｒｔｅｎｓｉｖｅｆａｃｔｏｒ，ＡＨＦ）对苯肾上腺素引起的Ｗｉｓｔａｒ大鼠胸主动脉螺旋条预收缩的舒张作用。结果表明：ＡＨＦ对主动脉条的舒张呈内皮与剂量依赖性。左旋硝基精氨酸与美蓝均可阻断ＡＨＦ的舒血管作用，而铜锌超氧化物歧化酶对ＡＨＦ的舒血管效应有促进作用。提示ＡＨＦ是通过刺激内皮细胞产生一氧化氨或其类似物，从而激活血管平滑肌细胞内可溶性鸟苷酸环化酶这一途径引起血管舒张的。
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| 关 键 词： | 大鼠，红细胞抗高血压因子，内皮依赖性，内皮舒张因子，一氧化氮 |
STUDIES ON THE MECHANISMS OF VASODILATORY EFFECT OF ERYTHEOCYTE
ANTIHYPERTENSIVE FACTOR |
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| Lu Tao,Wen Yunyi,Chen Mengqin.STUDIES ON THE MECHANISMS OF VASODILATORY EFFECT OF ERYTHEOCYTE
ANTIHYPERTENSIVE FACTOR[J].Chinese Journal of Applied Physiology,1994,10(1):5-8. |
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| Authors: | Lu Tao Wen Yunyi Chen Mengqin |
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| Abstract: | The vasodilatory effects of antihypertensive factor(AHF) extracted from
erythrocytes ofmale Sprague-Dawley rats on aortic strips of Wistar rats were studied. The aortic
strips wereprecontracted with phenylephrine,and relaxation percentages caused by AHF at
several concen-trations were monitored. AHF relaxed the aortic strips in an endothelium-and
dose-dependentmanner.Such effects could be abolished by both NG-nitro-L-arginine and
methylene blue, andenhaneed by Cu-Zn superoxide dismutase. The results suggest that AHF
might stimulate releaseof EDRF (nitric oxide or a nitric oxide related compound)from endothelial
ceells. EDRF could inturn activate soluble guanylate cyclase in the underlying vascular
smooth muscle cells, leading tovasodilation. |
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| Keywords: | rat erythrocyte antihypertensive factor endothelium dependency endothelium-derivedre-laxing factor nitric oxide |
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