| 低能量氦氖激光眼损伤的治疗研究 |
| |
| 引用本文： | 梁洁,康宏向,沈本剑,马琼,常爱红,郭华,严谨,陈鹏. 低能量氦氖激光眼损伤的治疗研究[J]. 激光生物学报, 2016, 0(4): 331-335. DOI: 10.3969/j.issn.1007-7146.2016.04.008 |
| |
| 作者姓名： | 梁洁 康宏向 沈本剑 马琼 常爱红 郭华 严谨 陈鹏 |
| |
| 作者单位： | 1. 军事医学科学院放射与辐射医学研究所,北京,100850;2. 甘肃省河西学院,甘肃 张掖,734300;3. 解放军 302 医院,北京,100039 |
| |
| 基金项目： | 国家自然科学基金资助项目(81000685；81072239；11304392)；北京市自然科学基金资助项目(7142124) |
| |
| 摘 要： | 探讨谷氨酸受体拮抗剂MK-801对激光视网膜损伤的治疗作用。建立氦氖激光的大鼠眼损伤模型,通过病理染色、免疫组化以及原位杂交等方法,观察照后即刻肌注MK-801(2 mg/kg)对视网膜损伤的保护作用。实验结果表明治疗组视网膜的形态结构均较对照组更完整,感光细胞层的厚度也多于对照组,同时,照后给予MK-801还可明显地减少视网膜损伤区域内NMDAR的表达。该实验结果对低能量激光视网膜损伤后的治疗具有参考意义。
|
| 关 键 词： | 激光 视网膜 损伤 谷氨酸受体拮抗剂 治疗 |
A Therapeutic Research on Low Energy He-Ne Laser Induced Retina Injury |
| |
| Abstract: | To study the therapeutic effect of MK-801 on laser-induced retina injury.The eyes of Wistar rats were ex-posed to He-Ne laser.The curative effects of MK-801 was observed by examination of histopathology and immunohisto-chemistry changes in the injuried region.Experimental results showed that comparing to the control group,better pre-served photoreceptors and reduced expression of NMDA were demonstrated in MK-801-treated rats,and so was the thick-ness of the photoreceptor cells.The experiment results should be helpful for clinical treating of retinal low energy laser injury. |
| |
| Keywords: | laser retina injury MK-801 therapy |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
