Prevention by bombesin of cold-restraint stress induced hemorrhagic lesions in rats |
| |
| Authors: | Y Taché P Simard R Collu |
| |
| Institution: | 1. Peptide Biology Laboratory, The Salk Institute, P.O. Box 1809, San Diego, CA 92112, USA;2. Pathology Department, San Diego, CA, USA;11. Endocrinology Laboratory, Centre de Recherche Pediatrique, Hôpital St. Justine, U. de Montréal, Montréal, Québec, CANADA |
| |
| Abstract: | Several neuropeptides, injected intraventricularly (ivt), were assessed for their effects on cold-restraint-induced hypothermia and hemorrhagic gastric lesions in 24 hr fasted rats. Bombesin (5-1 μg) further enhanced the drop in body temperature following stress and markedly prevented the gastric erosions in a dose-dependent fashion (5-0.1 μg). β-endorphin exerted a similar effect, but only at the 5 μg dose level. Other peptides (neurotensin, substance P, somatostatin and TRH: 5 μg) did not influence susceptibility to the gastric mucosal damage. Somatostatin and TRH reduced the hypothermic effect of stress. Bombesin is 250 times less potent when injected systemically than ivt and its actions are not reversed by nalaxone. The prevention of gastric erosions by bombesin could initially involve a central mechanism of action, independent of opiate receptors and possibly related to the sustained and marked hyperglycemia observed in bombesin treated rats exposed to stress. |
| |
| Keywords: | To whom reprint requests should be sent |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
