Effect of chronic ethanol consumption on basic carboxypeptidase activity in regions of the rat brain |
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| Authors: | Vernigora A N Mikhaĭlova O E Gengin M T Ryzhkova Iu A Mukhina E S |
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| Institution: | Penza State Pedagogical University, Russia. |
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| Abstract: | It is discovered that chronic consumption of ethanol induced decrease of carboxypeptidase H activity in striatum by 27%; increase of carboxypeptidase M activity in hippocampus by 67% and decrease in cerebral hemispheres by 34%; phenylmethylsulfonyl fluoride-inhibited carboxypeptidase activity increase in hypothalamus by 141%, in striatum by 60% and in optic and lamina quadrigemina by 34%. The role of basic carboxypeptidases in mechanisms of ethanol influence on the peptidergic systems are discussed. |
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