The compositional properties of human genes |
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Authors: | Brahim Aïssani Giuseppe D'Onofrio Dominique Mouchiroud Katheleen Gardiner Christian Gautier Giorgio Bernardi |
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Affiliation: | (1) Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France;(2) Laboratoire de Biométrie, Génétique et Biologie des Populations, U.R.A. 243, Université Claude Bernard, 69600 Villeurbanne, France;(3) Eleanor Roosevelt Institute for Cancer Research, 1899 Gaylord Street, 80202 Denver, CO, USA;(4) Present address: Stazione Zoologica, Villa Comunale, 80121 Naples, Italy |
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Abstract: | Summary The present work represents the first attempt to study in greater detail previously proposed compositional correlations in genomes, based on a body of additional data relating to gene localizations as well as to extended flanking sequences extracted from gene banks. We have investigated the correlations that exist between (1) the GC levels of exons of human genes, and (2) the GC levels of either intergenic sequences or introns associated with the genes under consideration. In both cases, linear relationships with slopes close to unity were found. The similarity of the linear relationships indicates similar GC levels in intergenic sequences and introns located in the same isochores. Moreover, both intergenic sequences and introns showed GC levels 5–10% lower than the corresponding exons. The above findings considerably strengthen the previously drawn conclusion that coding and noncoding sequences (both inter- and intragenic) from the same isochores of the human genome are compositionally correlated. In addition, we find linear correlations between the GC levels of codon positions and of the intergenic sequences or introns associated with the corresponding genes, as well as among the GC levels of codon positions of genes. |
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Keywords: | Human genome Gene localization Isochores Coding sequences Introns Codon positions |
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