Microarray analysis of the developing rat mandible |
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Authors: | Kaburagi Hideo Sugano Naoyuki Oshikawa Maiko Koshi Ryosuke Senda Naoki Kawamoto Kazuhiro Ito Koichi |
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Institution: | Department of Periodontology, Nihon University School of Dentistry, Tokyo 101-8310, Japan. |
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Abstract: | To analyze the molecular events that occur in the developing mandible, we examined the expression of 8803 genes from samples taken at different time points during rat postnatal mandible development. Total RNA was extracted from the mandibles of 1-day-old, 1-week-old, and 2-week-old rats. Complementary RNA (cRNA) was synthesized from cDNA and biotinylated. Fragmented cRNA was hybridized to RGU34A GeneChip arrays. Among the 8803 genes tested, 4344 were detectable. We identified 148 genes with significantly increased expression, and 19 genes with significantly decreased expression. A comprehensive analysis appears to be an effective method of studying the complex process of development. |
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Keywords: | gene expression microarray rat mandible |
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