Synthesis and antiviral evaluation of some new pyrazole and fused pyrazolopyrimidine derivatives

Some novel substituted pyrazole and pyrazolo3,4-d]pyrimidine derivatives 2, 4, 8, and 9 were synthesized. Also, some acyclic S-nucleosides of pyrazolo3,4-d]pyrimidine derivatives 10-13 were prepared via reaction of pyrazolo3,4-d]pyrimidine-4(3H)-thione derivative 9 with some acyclic sugars. Moreover, the N-nucleoside derivative 14 was prepared via reaction of compound 8 with glucosamine hydrochloride. The antiviral evaluation of some selected new products showed that they have promising antiviral activity against hepatitis-A virus (HAV) and herpes simplex virus type-1 (HSV-1).