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Extracellular tau is toxic to neuronal cells
Authors:Gómez-Ramos Alberto  Díaz-Hernández Miguel  Cuadros Raquel  Hernández Félix  Avila Jesús
Institution:Centro de Biología Molecular Severo Ochoa, Facultad de Ciencias, Campus de Cantoblanco, Universidad Autónoma de Madrid, 28049-Madrid, Spain.
Abstract:The degeneration of neurons in disorders such as Alzheimer's disease has an immediate consequence, the release of intracellular proteins into the extracellular space. One of these proteins, tau, has proven to be toxic when added to cultured neuronal cells. This toxicity varies according to the degree of protein aggregation. The addition of tau to cultured neuroblastoma cells provoked an increase in the levels of intracellular calcium, which is followed by cell death. We suggest that this phenomenon may be mediated by the interaction of tau with muscarinic receptors, which promotes the liberation of calcium from intracellular stores.
Keywords:  beta amyloid peptide  AD  Alzheimer’s disease  EC  entorhinal cortex  MT  microtubule  NFT  neurofibrillary tangles  PHF  paired helical filaments
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