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SGP28, a novel matrix glycoprotein in specific granules of human neutrophils with similarity to a human testis-specific gene product and to a rodent sperm-coating glycoprotein
Authors:Lars Kjeldsen  Jack B Cowland  Anders H Johnsen  Niels Borregaard
Institution:aGranulocyte Research Laboratory, Department of Hematology, The Finsen Center, Rigshospitalet, Denmark;bDepartment of Clinical Biochemistry, The National University Hospital, Rigshospitalet, Denmark
Abstract:A novel 28 kDa glycoprotein was purified from exocytosed material from human neutrophils and its primary structure partially determined. Degenerate oligonucleotide primers were used to amplify cDNA clones from a human bone marrow cDNA library. The deduced 245 amino acid sequence of the 2124 bp full-length cDNA showed high degrees of similarity to the deduced sequences of the human gene TPX-1 and of sperm coating glycoprotein from rat and mouse. Subcellular fractionation of human neutrophils indicated that the protein is localized in specific granules. The protein was named SGP28 (specific granule protein of 28 kDa).
Keywords:TPX-1  Acidic epididymal glycoprotein  Pathogenesis related protein 1  Subcellular fractionation
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