Diterpenes from the Roots of Oryza sativa L. and Their Inhibition Activity on NO Production in LPS‐Stimulated RAW264.7 Macrophages |
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| Authors: | Jin‐Gyeong Cho Byeong‐Ju Cha Sang Min?Lee Sabina Shrestha Rak‐Hun Jeong Dong Sung?Lee Youn‐Chul Kim Dong‐Geol Lee Hee‐Cheol Kang Jiyoung Kim Nam‐In Baek |
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| Institution: | 1. Graduate School of Biotechnology and Research Institute of Life Sciences & Resources, Kyung Hee University, Yongin 446‐701, Republic of Korea, (phone: +82‐31‐201‐2610;2. fax: +82‐31‐204‐8116);3. Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Won Kwang University, Iksan 570‐749, Republic of Korea;4. R&D Center, GFC Co., Ltd., Suwon 443‐813, Republic of Korea |
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| Abstract: | Two new pimarane diterpenoids, momilactone D ( 3 ) and momilactone E ( 5 ), along with three known diterpenoids, momilactone A ( 1 ), sandaracopimaradien‐3‐one ( 2 ), and oryzalexin A ( 4 ) were isolated from Oryza sativa roots. The chemical structures of the compounds were determined by spectroscopic data analysis. The isolated diterpenoids were evaluated for their ability to inhibit NO production and iNOS mRNA and protein expression in LPS‐stimulated RAW264.7 macrophages. Compound 4 showed strong inhibition activity on NO production, and compounds 1 and 4 decreased the expression of iNOS mRNA and protein levels. |
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| Keywords: | iNOS Momilactone D Momilactone E NO Production RAW264 7 Rice roots |
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