Microsphaerol and Seimatorone: Two New Compounds Isolated from the Endophytic Fungi,Microsphaeropsis sp. and Seimatosporium sp. |
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| Authors: | Hidayat Hussain Natalia Root Farah Jabeen Ahmed Al‐Harrasi Manzoor Ahmad Fazal Mabood Zahid Hassan Afzal Shah Ivan R Green Barbara Schulz Karsten Krohn |
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| Institution: | 1. Department of Chemistry, University of Paderborn, Warburger Strasse 100, DE‐33098 Paderborn, (phone: +49‐5251‐602172;2. fax: +49‐5251‐603245);3. UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, P.O. Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Sultanate of Oman;4. Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan;5. Department of Chemistry, Quaid‐i‐Azam University, 45320 Islamabad, Pakistan;6. Department of Chemistry and Polymer Science, University of Stellenbosch, P/Bag X1 Matieland 7602, South Africa;7. Institute of Microbiology, University of Braunschweig, Spielmannstra?e 7, DE‐38106 Braunschweig |
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| Abstract: | A new polychlorinated triphenyl diether named microsphaerol ( 1 ), has been isolated from the endophtic fungus Microsphaeropsis sp. An intensive phytochemical investigation of the endophytic fungus Seimatosporium sp., led to the isolation of a new naphthalene derivative named seimatorone ( 2 ) and eight known compounds, i.e., 1‐(2,6‐dihydroxyphenyl)‐3‐hydroxybutan‐1‐one ( 3 ), 1‐(2,6‐dihydroxyphenyl)butan‐1‐one ( 4 ), 1‐(2‐hydroxy‐6‐methoxyphenyl)butan‐1‐one ( 5 ), 5‐hydroxy‐2‐methyl‐4H‐chromen‐4‐one ( 6 ), 2,3‐dihydro‐5‐hydroxy‐2‐methyl‐4H‐chromen‐4‐one ( 7 ), 8‐methoxynaphthalen‐1‐ol ( 8 ), nodulisporins A and B ( 9 and 10 , resp.), and daldinol ( 11 ). The structures of 1 and 2 were elucidated by detailed spectroscopic analysis including 1H‐ and 13C‐NMR, COSY, HMQC, HMBC, and HR‐EI‐MS, while the structures of the known compounds were deduced from comparison of their spectral data with those in the literature. Preliminary studies revealed that microsphaerol ( 1 ) showed good antibacterial activities against B. Megaterium and E. coli, and good antilagal and antifungal activities against C. fusca, M. violaceum, respectively. On the other hand, seimatorone ( 2 ) exhibited moderate antibacterial, antialgal, and antifungal activities. |
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| Keywords: | Diether Endophytic fungi Antifungal activity Microsphaeropsis Antibacterial activity Seimatosporium Naphthalene‐2‐carbaldehyde |
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