Insecticidal and Repellant Activities of Polyacetylenes and Lactones Derived from Atractylodes lancea Rhizomes |
| |
| Authors: | Hai‐Ping Chen Li‐Shi Zheng Kai Yang Ning Lei Zhu‐Feng Geng Ping Ma Qian Cai Shu‐Shan Du Zhi‐Wei Deng |
| |
| Affiliation: | 1. College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, P.?R. China (phone: +86‐411‐85890125);2. Protection and Utilization of Traditional Chinese Medicine of Beijing Area Major Laboratory, College of Resources Science and Technology, Beijing Normal University, No.?19 Xinjiekouwai Street, Beijing 100875, P.?R. China (phone/fax: +86‐10‐62208022);3. Department of Pharmacy General Hospital of Second Artillery, PLA, No.?16 Xinjiekouwai Street, Beijing 100088, P.?R. China;4. Analytical and Testing Center, Beijing Normal University, No.?19 Xinjiekouwai Street, Beijing 100875, P.?R. China |
| |
| Abstract: | During a screening program for new agrochemicals from Chinese medicinal herbs and local wild plants, the petroleum ether (PE) extract of Atractylodes lancea (Thunb. ) rhizomes was found to possess repellent and contact activities against Tribolium castaneum adults. Bioactivity‐directed chromatographic separation of PE extract on repeated silica‐gel columns led to the isolation of two polyacetylenes, atractylodin and atractylodinol ( 1 and 2 , resp.), and two lactones, atractylenolides II and III ( 3 and 4 , resp.). The structures of the compounds were elucidated based on NMR spectra. The four isolated compounds were evaluated for their insecticidal and repellent activities against T. castaneum. Atractylodin exhibited strong contact activity against T. castaneum adults with a LD50 value of 1.83 μg/adult. Atractylodin and atractylenolide II also possessed strong repellenct activities against T. castaneum adults. After 4‐h exposure, >90% repellency was achieved with atractylodin at a low concentration of 0.63 μg/cm2. The results indicated that atractylodin ( 1 ) and atractylenolide II ( 3 ) have a good potential as a source for natural repellents, and 1 has the potential to be developed as natural insecticide. |
| |
| Keywords: | Atractylodes lancea Tribolium castaneum Contact toxicity Repellency Atractylodin Atractylenolides II and III |
|
|
