Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors |
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| Authors: | Chen Bin Petukhov Pavel A Jung Mira Velena Alfredo Eliseeva Elena Dritschilo Anatoly Kozikowski Alan P |
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| Affiliation: | Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. |
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| Abstract: | A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better HDAC inhibitory activity than SAHA. |
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