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Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists |
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| Authors: | Yamamoto Takashi Fujita Koichi Asari Sayaka Chiba Akira Kataba Yuka Ohsumi Koji Ohmuta Naoko Iida Yuko Ijichi Chiori Iwayama Satoshi Fukuchi Naoyuki Shoji Masataka |
| Affiliation: | Pharmaceutical Research Laboratories, Ajinomoto Company Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki-shi 210-8681, Japan. |
| Abstract: | A series of isoxazole derivatives were synthesized and their antagonistic activities against LPA stimulation on both LPA(1)/CHO cells and rHSC cells were evaluated. Among them, 3-(4-[4-[1-(2-chloro-cyclopent-1-enyl)-ethoxycarbonylamino]-isoxazol-3- y]]-benzylsulfanyl)-propionic acid (34) showed the most potent activities. |
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