Stem cell niches: famished paneth cells, gluttonous stem cells |
| |
| Authors: | Tae-Hee Kim Ramesh A Shivdasani |
| |
| Affiliation: | Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA, and Department of Medicine, Brigham & Women''s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA |
| |
| Abstract: | Adult tissue stem cells adjust to environmental changes. A new study in the?mouse intestine reveals that caloric restriction causes Paneth cells to repress mTORC1 signaling; this in turn stimulates proliferation of neighboring stem cells. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
