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Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3 |
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| Authors: | Karina N Gonzalez Herrera Elma Zaganjor Yoshinori Ishikawa Jessica B Spinelli Haejin Yoon Jia-Ren Lin F Kyle Satterstrom Alison Ringel Stacy Mulei Amanda Souza Joshua M Gorham Craig C Benson Jonathan G Seidman Peter K Sorger Clary B Clish Marcia C Haigis |
| Institution: | 1. Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA;2. Ludwig Center for Cancer Research at Harvard, Boston, MA 02115, USA;3. Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA;4. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA;5. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA;6. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA |
| Abstract: |  |
| Keywords: | mitochondria SIRT3 sirtuin glutamine nucleotide synthesis mTORC1 azaserine proliferation small-molecule screen |
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