Beh?et's disease |
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Authors: | Shunsei Hirohata and Hirotoshi Kikuchi |
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Institution: | (1) Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan |
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Abstract: | Beh?et's disease is characterized by recurrent aphthous stomatitis, uveitis, genital ulcers, and skin lesions. The role of
the HLA-B*51 gene has been confirmed in recent years, although its contribution to the overall genetic susceptibility to Beh?et's disease
was estimated to be only 19%. The production of a variety of cytokines by T cells activated with multiple antigens has been
shown to play a pivotal role in the activation of neutrophils. As regards the treatment, anti-tumor necrosis factor alpha
therapy has been shown to be effective for mucocutaneous symptoms as well as for sight-threatening panuveitis, although a
randomized, controlled trial is required. |
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Keywords: | |
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