Studies on chloride permeability of the skin ofLeptodactylus ocellatus: I. Na+ and Cl− effect on passive movements of Cl− |
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Authors: | M. V. Ques-von Petery C. A. Rotunno M. Cereijido |
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Affiliation: | (1) Department of Biophysics, Albert Einstein Center of Medical Research (CIMAE), Luis Viale 2831, Buenos Aires, Argentina;(2) Centro de Investigación y Estudios Avanzados del IPN of México, Apartado Postal 14-740, México 14, D.F.;(3) Present address: Dept. of Fisiología, Centro de Investigaciones del IPN, Apartado Postal 14-740, México 14, D.F., Mexico |
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Abstract: | Summary The outflux of chloride through the isolated skin (J31Cl) of the South American frogLeptodactylus ocellatus (L.) is carried by a mechanism that saturates at high concentration of chloride on the inside, and is stimulated by the presence of Cl– in the outer solution (trans side). The presence of Na+ on the outside, by itself, does not increaseJ31Cl. However, whenJ31Cl is already increased by chloride on thetrans side, the addition of Na+ produces a significant further increase. At low concentration of Cl– on the outsideJ31Cl proceeds through a route which involves changes in electrical parameters. The results suggest that both mechanisms are located on the cell membranes and, therefore, that the fluxes would cross through the cytoplasm of the cells. Na+ stimulates the second mechanism only. |
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