Inhibition of BMP signaling in P-Cadherin positive hair progenitor cells leads to trichofolliculoma-like hair follicle neoplasias |
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| Authors: | Lixin Kan Yijie Liu Tammy L McGuire Michael A Bonaguidi John A Kessler |
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| Affiliation: | (1) Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;(2) Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA;(3) Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA |
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| Abstract: | Background Skin stem cells contribute to all three major lineages of epidermal appendages, i.e., the epidermis, the hair follicle, and the sebaceous gland. In hair follicles, highly proliferative committed progenitor cells, called matrix cells, are located at the base of the follicle in the hair bulb. The differentiation of these early progenitor cells leads to specification of a central hair shaft surrounded by an inner root sheath (IRS) and a companion layer. Multiple signaling molecules, including bone morphogenetic proteins (BMPs), have been implicated in this process. |
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| Keywords: | Transgenic Mice Nse-Noggin bone morphogenetic protein (BMP) trichofolliculoma |
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