Secondary metabolites from Commiphora opobalsamum and their antiproliferative effect on human prostate cancer cells |
| |
Authors: | Shen Tao Wan Wenzhu Yuan Huiqing Kong Feng Guo Huaifang Fan Peihong Lou Hongxiang |
| |
Institution: | Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China. |
| |
Abstract: | A cycloartane-type triterpenoid (1), an aliphatic alcohol glycoside (2), an eudesmane-type sesquiterpenoid (3), and a guaiane-type sesquiterpenoid (4) were isolated from the resinous exudates of Commiphora opobalsamum along with six known sesquiterpenoids (5-10). Their structures were established by extensive analysis of their 1D and 2D NMR spectroscopic data and chemical methods. The isolated compounds 1-3 and 5-9 were tested against human prostate cancer cell PC 3 and LNCaP. Among them, 1 and 2 showed moderate antiproliferative effects on human prostate cancer cell lines with IC50 values ranging from 5.7 to 23.6 microM; they were also able to inhibit the expression of androgen receptor (AR) in LNCaP cells. The six sesquiterpenoids were inactive in the bioassays. |
| |
Keywords: | Commiphora opobalsamum Burseraceae Triterpenoid Aliphatic alcohol glycoside Sesquiterpenoid Antiproliferative Prostate cancer cells |
本文献已被 ScienceDirect PubMed 等数据库收录! |