Identification of baboon microRNAs expressed in liver and lymphocytes |
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| Authors: | Genesio M Karere Jeremy P Glenn John L VandeBerg Laura A Cox |
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| Affiliation: | (1) Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, 78227 San Antonio, TX, USA;(2) Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, 78227 San Antonio, TX, USA |
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| Abstract: | Background MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides) that regulate gene expression by cleaving mRNAs or inhibiting translation. The baboon is a well-characterized cardiovascular disease model; however, no baboon miRNAs have been identified. Evidence indicates that the baboon and human genomes are highly conserved; based on this conservation, we hypothesized that comparative genomic methods could be used to identify baboon miRNAs. |
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