Photodynamic cell-kill analysis of breast tumor cells with a tamoxifen-pyropheophorbide conjugate |
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Authors: | Fernandez Gacio Ana Fernandez-Marcos Carlos Swamy Narasimha Dunn Darra Ray Rahul |
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Institution: | Bioorganic Chemistry and Structural Biology, Section in Endocrinology, Diabetes and Metabolism, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA. |
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Abstract: | We hypothesized that estrogen receptor (ER) in hormone-sensitive breast cancer cells could be targeted for selective photodynamic killing of tumor cell with antiestrogen-porphyrin conjugates by combining the over-expression of ER in hormone-sensitive breast cancer cells and tumor-retention property of porphyrin photosensitizers. In this study we describe that a tamoxifen (TAM)-pyropheophorbide conjugate that specifically binds to ER alpha, caused selective cell-kill in MCF-7 breast cancer cells upon light exposure. Therefore, it is a potential candidate for ER-targeted photodynamic therapy of cancers (PDT) of tissues and organs that respond to estrogens/antiestrogens. |
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Keywords: | estrogen receptor targeted delivery of phototoxins tamoxifen‐porphyrin conjugate photodynamic cell‐kill breast cancer |
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