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Effect of intranasal arginine vasopressin on human headache
Authors:Jun Yang  Lu Lu  Hong-Chang Wang  He-Qin Zhan  Guang-Fan Hai  Yan-Juan Pan  Qiong-Qing Lv  Da-Xin Wang  Yu-Quan Wu  Ren-Ren Li  Lei Xue  Xin-Hua Wang  Xiao-Ming Deng  Xin-Feng Liu  Yan-Ning Qian  Zhi-Kuan Deng  Zhi-Jian Zhang  Xin-Huan Zhan  Xin-Jian Zhou  Guo-Liang Wang  Jian-Xin Zhai  Jing-Cheng Wang
Institution:1. College of Pharmacy, Xinxiang Medical University, Xinxiang, Henan 453003, China;2. Academician Workstation for Neuropsychiatry Pharmacological Research of Henan Province, Xinxiang Medical University, Xinxiang, Henan 453003, China;3. Henan Provincial Mental Hospital, Xinxiang Medical University, Xinxiang, Henan 453002, China;4. Biomedical Engineering Laboratory, Jiangsu Su Bei People''s Hospital, Yangzhou University, Yangzhou, Jiangsu 225001, China;5. Department of Geriatrics, 117 Hospital of People''s Liberation Army, Hangzhou, Zhejiang 310013, China;6. Department of Anesthesia, Guangdong 999 Brain Hospital, Guangzhou, Guangdong 510510, China;g Department of Hyperbaric Oxygen, Nanfang Hospital, Nanfang Medical University, Guangzhou, Guangdong 510515, China;h Department of Anesthesia, Dongfang Hospital, Tongji University, Shanghai 200120, China;i Department of Anesthesia, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;j Department of Neurology, Nanjing General Hospital in Nanjing Military Area Command, Nanjing, Jiangsu 210002, China;k Department of Anesthesia, Jiangsu Provincial People''s Hospital, Nanjing, Jiangsu 210029, China;l Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China;m Department of Internal Medicine, Fuzhou General Hospital in Nanjing Military Area Command, Fuzhou, Fujian 350001, China;n Department of Surgery, 95 Hospital of People''s Liberation Army, Putian, Fujian 351100, China;o Department of Internal Medicine, 101 Hospital of People''s Liberation Army, Wuxi, Jiangsu 214000, China;p Department of Brain Surgery, Guangzhou General Hospital in Guangzhou Military Area Command, Guangzhou, Guangdong 510000, China;q Department of Surgery, The Fourth People''s Hospital, Wuxi, Jiangsu 214062, China
Abstract:Arginine vasopressin (AVP), a nonapeptide hormone of posterior pituitary, reaches the central nervous system from systemic blood circulation with a difficulty because of the blood–brain barrier (BBB). The interest has been expressed in the use of the nasal route for delivery of AVP to the brain directly, exploiting the olfactory pathway. Our previous study has demonstrated that AVP in the brain rather than the spinal cord and blood circulation plays an important role in rat pain modulation. For understanding the role of AVP on pain modulation in human, the communication tried to investigate the effect of intranasal AVP on human headache. The results showed that (1) AVP concentration in both plasma and cerebrospinal fluid (CSF) increased significantly in headache patients, who related with the headache level; (2) there was a positive relationship between plasma and CSF AVP concentration in headache patients; and (3) intranasal AVP could relieve the human headache in a dose-dependent manner. The data suggested that intranasal AVP, which was delivered to the brain through olfactory region, could treat human headache and AVP might be a potential drug of pain relief by intranasal administration.
Keywords:Arginine vasopressin  Headache  Intranasal administration  Human
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