Expression of human MxA protein in mosquito cells interferes with LaCrosse virus replication |
| |
| Authors: | Miura T A Carlson J O Beaty B J Bowen R A Olson K E |
| |
| Institution: | Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523 USA. |
| |
| Abstract: | Human MxA protein inhibits LaCrosse virus (LAC virus; family Bunyaviridae) replication in vertebrate cells and MxA-transgenic mice. LAC virus is transmitted to humans by Aedes triseriatus mosquitoes. In this report, we have shown that transfected mosquito cells expressing the human MxA cDNA are resistant to LAC virus but permissive for Sindbis virus (family Togaviridae) infection. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
