Specific binding of 3H-estradiol to rat prostate nuclear matrix |
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| Authors: | G E Swaneck J M Alvarez |
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| Affiliation: | 1. The Rockefeller University, New York, N.Y. 10021 USA;2. Washington University School of Medicine, St. Louis, MO 63110 USA;1. Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, Campus Gasthuisberg ON1 Herestraat 49 - box 901, Leuven 3000, Belgium;2. Department of Chemistry, Laboratory of Biomolecular Modelling and Design, Heverlee 3001, Belgium;1. Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales de la Universidad de Buenos Aires, Buenos Aires, 1428, Argentina;2. Instituto de Química Biológica de la, Facultad de Ciencias Exactas y Naturales, CONICET, Buenos Aires, 1428, Argentina;3. Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, 1428, Argentina |
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| Abstract: | Specific estradiol binding activities can be demonstrated in nuclear matrix preparations obtained from intact rat prostate nuclei. Some of the characteristics of these in vitro binding activities to intranuclear components are presented and compared to those exhibited by purified nuclear fractions. Examination of the effects of exposure to castration and testosterone on the number of nuclear matrix binding sites revealed that the quantity and quality (Type) of receptors was modified. Furthermore, these changes are prevented when protein synthesis was inhibited. |
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