CancerLectinDB: a database of lectins relevant to cancer |
| |
Authors: | Deepa Damodaran Justin Jeyakani Alok Chauhan Nirmal Kumar Nagasuma R Chandra Avadhesha Surolia |
| |
Institution: | (1) Bioinformatics Centre and Supercomputer Education and Research Centre, Indian Institute of Science, Raman Building, Bangalore, 560 012, India;(2) Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560 012, India;(3) National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110 067, India |
| |
Abstract: | The role of lectins in mediating cancer metastasis, apoptosis as well as various other signaling events has been well established
in the past few years. Data on various aspects of the role of lectins in cancer is being accumulated at a rapid pace. The
data on lectins available in the literature is so diverse, that it becomes difficult and time-consuming, if not impossible
to comprehend the advances in various areas and obtain the maximum benefit. Not only do the lectins vary significantly in
their individual functional roles, but they are also diverse in their sequences, structures, binding site architectures, quaternary
structures, carbohydrate affinities and specificities as well as their potential applications. An organization of these seemingly
independent data into a common framework is essential in order to achieve effective use of all the data towards understanding
the roles of different lectins in different aspects of cancer and any resulting applications. An integrated knowledge base
(CancerLectinDB) together with appropriate analytical tools has therefore been developed for lectins relevant for any aspect
of cancer, by collating and integrating diverse data. This database is unique in terms of providing sequence, structural,
and functional annotations for lectins from all known sources in cancer and is expected to be a useful addition to the number
of glycan related resources now available to the community. The database has been implemented using MySQL on a Linux platform
and web-enabled using Perl-CGI and Java tools. Data for individual lectins pertain to taxonomic, biochemical, domain architecture,
molecular sequence and structural details as well as carbohydrate specificities. Extensive links have also been provided for
relevant bioinformatics resources and analytical tools. Availability of diverse data integrated into a common framework is
expected to be of high value for various studies on lectin cancer biology. CancerLectinDB can be accessed through .
Availability: CancerLectinDB is available freely for academic use from , Contact nchandra@serc.iisc.ernet.in for further information. |
| |
Keywords: | Cancer Lectins Taxonomic Biochemical Domain architecture Sequence Carbohydrate specificities Database |
本文献已被 PubMed SpringerLink 等数据库收录! |
|