Coincident detection of CSF Na+ and osmotic pressure in osmoregulatory neurons of the supraoptic nucleus |
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Authors: | Voisin D L Chakfe Y Bourque C W |
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Institution: | Centre for Research in Neuroscience, Montréal General Hospital and McGill University, Québec, Canada. |
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Abstract: | Behavioral and neuroendocrine responses underlying systemic osmoregulation are under the concerted control of centrally located osmoreceptors and cerebrospinal fluid (CSF) Na+ concentration (Na+]) detectors. Although the process underlying osmoreception is understood, the mechanism by which Na+] is detected and integrated with cellular information derived from osmoreceptors is unknown. Here, we show that shifts in extracellular Na+] (Na+]0) cause proportional changes in the relative Na+ permeability of mechanosensitive cation channels responsible for signal transduction in the osmosensory neurons of the supraoptic nucleus. This effect causes the generation of Na+ specific receptor potentials under isotonic conditions and modulates osmoreceptor potentials and electrical responsiveness during osmotic perturbation. These results provide a cellular basis for Na+-sensing and for the coordinated detection of CSF Na+] and osmolality in central osmoregulatory neurons. |
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