A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues |
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| Authors: | Kiburu Irene Shurer Andrew Yan Lei Sintim Herman O |
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| Affiliation: | Department of Chemistry and Biochemistry, Building 091, University of Maryland, College Park, MD 20742, USA. hsintim@umd.edu. |
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| Abstract: | Cyclic-di-guanylate (c-di-GMP) has emerged as a general and important signaling molecule uniquely present in bacteria: herein we provide a simple solid-phase synthesis of c-di-GMP using an automated DNA synthesizer for the majority of the synthesis. |
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