Short oligodeoxynucleotides with d(G-C)n sequence do not assume left-handed conformation in high salt conditions |
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Authors: | F Quadrifoglio G Manzini N Yathindra |
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Affiliation: | Department of Biology Indiana University Bloomington, IN, U.S.A. |
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Abstract: | d(G-C)n oligodeoxynucleotides (with n varying from 3 to 7) were studied by the circular dichroism technique in 5 M-NaCl. Contrary to what was previously found with the d(C-G)n series in the same solvent, the left-handed double-stranded Z-conformation appears less stable than the B-form for low n values. The influence of base sequence on the relative stability of B- and Z-conformations for the two series is discussed. |
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