Uterine stimulant action of some 16-phenoxy analogues of (+)-11-deoxyprostaglandin E1 |
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Authors: | MPL Caton ECJ Coffee DJ Hambling CJ Hardy MN Palfreyman |
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Institution: | The Research Laboratories, May & Baker Ltd., Dagenham, Essex, RM10 7XS, England |
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Abstract: | Some ()-11-deoxy-16-phenoxyprostaglandin E1 analogues have been evaluated as uterine stimulants in the anaesthetised pregnant rat. Gastrointestinal side effects, assessed by the antagonism of morphine-induced consitpation in the mouse, were relatively low with some of these compounds, six of which had a much more favourable relative selectivity than 16,16-dimethyl1-PGE2 methyl ester. |
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