Use of antibiotic disks to evolve drug-resistant bacteria |
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Authors: | J Nicole Flanagan Todd R Steck |
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Institution: | 1.Department of Biological Sciences,Univ. of North Carolina at Charlotte,Charlotte,USA |
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Abstract: | The methods used to generate antibiotic-resistant bacterial strains can be labour-intensive, costly, lengthy and/or prone to plate-to-plate variation. We propose a simple, inexpensive and easily replicated method to expose bacteria to a continuous gradient of antibiotic concentration, providing an environment of positive selective pressure for evolution of antibiotic-resistant strains. |
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