Transcriptome map of mouse isochores in embryonic and neonatal cortex |
| |
| Authors: | Kimon Frousios Costas S. Iliopoulos German Tischler Sophia Kossida Solon P. Pissis Stilianos Arhondakis |
| |
| Affiliation: | 1. Department of Informatics, King''s College London, The Strand, London WC2R 2LS, UK;2. School of Mathematics and Statistics, University of Western Australia, 35 Stirling Highway, Crawley, Perth WA 6009, Australia;3. Lehrstuhl für Informatik 2, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany;4. Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou, Athens 115 27, Greece;5. Florida Museum of Natural History, University of Florida, 1659 Museum Road, Gainesville, FL 32611, USA;6. Heidelberg Institute for Theoretical Studies, 35 Schloss-Wolfsbrunnenweg, Heidelberg D-69118, Germany |
| |
| Abstract: | Several studies on adult tissues agree on the presence of a positive effect of the genomic and genic base composition on mammalian gene expression. Recent literature supports the idea that during developmental processes GC-poor genomic regions are preferentially implicated. We investigate the relationship between the compositional properties of the isochores and of the genes with their respective expression activity during developmental processes. Using RNA-seq data from two distinct developmental stages of the mouse cortex, embryonic day 18 (E18) and postnatal day 7 (P7), we established for the first time a developmental-related transcriptome map of the mouse isochores. Additionally, for each stage we estimated the correlation between isochores' GC level and their expression activity, and the genes' expression patterns for each isochore family. Our analyses add evidence supporting the idea that during development GC-poor isochores are preferentially implicated, and confirm the positive effect of genes' GC level on their expression activity. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
