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Fine mapping of the 1q21 breakpoint of the papillary renal cell carcinoma-associated (X;1) translocation |
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| Authors: | M. A. J. Weterman Monique Wilbrink Trijnie Dijkhuizen Eva van den Berg Ad Geurts van Kessel |
| Affiliation: | (1) Department of Human Genetics, University Hospital Nijmegen, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands Tel.: (+)31.24.3614107; Fax: (+)31.24.3540488, NL;(2) Department of Medical Genetics, University of Groningen, The Netherlands, NL |
| Abstract: | A combination of Southern blot analysis on a panel of tumor-derived somatic cell hybrids and fluorescence in situ hybridization (FISH) techniques was used to map a series of DNA markers relative to the 1q21 breakpoint of the renal cell carcinoma (RCC)-associated (X;1)(p11;q21) translocation. This breakpoint maps between several members of the S100 family which are clustered in the 1q21 region and a conserved region between man and mouse containing the markers SPTA1-CRP-APCS-FcER1A-ATP1A2-APOA2. The location of the breakpoint coincides with the transition of a region of synteny of human chromosome 1 with mouse chromosomes 3 and 1. Received: 10 November 1995 / Revised: 3 February 1996 |
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