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Mathematical model for empirically optimizing large scale production of soluble protein domains |
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| Authors: | Eisuke Chikayama Atsushi Kurotani Takanori Tanaka Takashi Yabuki Satoshi Miyazaki Shigeyuki Yokoyama Yutaka Kuroda |
| Affiliation: | (1) Genomic Sciences Center RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku Yokohama, 230-0045, Japan;(2) Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku Tokyo, 113-0033, Japan;(3) Department of Biotechnology and Life Science, Faculty of Technology, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei Tokyo, 184-0012, Japan |
| Abstract: | BackgroundEfficient dissection of large proteins into their structural domains is critical for high throughput proteome analysis. So far, no study has focused on mathematically modeling a protein dissection protocol in terms of a production system. Here, we report a mathematical model for empirically optimizing the cost of large-scale domain production in proteomics research. |
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