Characterization of JG024, a pseudomonas aeruginosa PB1-like broad host range phage under simulated infection conditions |
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| Authors: | Julia Garbe Andrea Wesche Boyke Bunk Marlon Kazmierczak Katherina Selezska Christine Rohde Johannes Sikorski Manfred Rohde Dieter Jahn Max Schobert |
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| Affiliation: | 1.Institute of Microbiology,Technische Universit?t Braunschweig,Braunschweig,Germany;2.DSMZ,German Collection of Microorganisms and Cell Cultures,Braunschweig,Germany;3.HZI, Helmholtz Centre for Infection Research,Braunschweig,Germany |
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| Abstract: | Background Pseudomonas aeruginosa causes lung infections in patients suffering from the genetic disorder Cystic Fibrosis (CF). Once a chronic lung infection is established, P. aeruginosa cannot be eradicated by antibiotic treatment. Phage therapy is an alternative to treat these chronic P. aeruginosa infections. However, little is known about the factors which influence phage infection of P. aeruginosa under infection conditions and suitable broad host range phages. |
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