Histone synthesis is not coupled to the replication of adenovirus DNA |
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| Authors: | G Tallman J E Akers B T Burlingham G R Reeck |
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| Affiliation: | 1. Division of Biology Kansas State University, Manhattan, Kansas 66506 USA;2. Department of Biochemistry Kansas State University, Manhattan, Kansas 66506 USA;3. Department of Microbiology, East Carolina University Greenville, North Carolina 27834 USA |
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| Abstract: | Histone synthesis decreases approximately in parallel with the decrease in cellular DNA synthesis when KB cell monolayers are productively infected with adenovirus type 2 and does not occur in coordination with the later surge of viral DNA synthesis. The synthesis of histones is not, therefore, required for all replicative DNA synthesis in the nuclei of mammalian cells. |
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| Keywords: | Reprints may be obtained from either Dr. Burlingham (East Carolina University) or Dr. Reeck. |
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