Facile preparation of mono-2-O-modified eicosa-O-methylcyclomaltoheptaoses (-beta-cyclodextrins) |
| |
Authors: | Suzuki Masato Nozoe Yutaka |
| |
Institution: | Department of Organic and Polymeric Materials, Graduate School of Science and Engineering, and International Research Center of Macromolecular Science, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Japan. msuzuki@polymer.titech.ac.jp |
| |
Abstract: | Mono-2-O-benzylated eicosa-O-methylcyclomaltoheptaose (-beta-cyclodextrin) was prepared in one pot from cyclomaltoheptaose (beta-cyclodextrin) in 33% isolated yield and quantitatively converted to mono-2-OH-free eicosa-O-methylcyclomaltoheptaose, which is the key compound for further modification. Transformation of this 2-OH group successfully gave several mono-2-O-modified eicosa-O-methylcyclomaltoheptaoses such as the acetate, the N,N-dimethylcarbamate, the N-n-butylcarbamate, the methanesulfonate, and the S-methyldithiocarbonate. |
| |
Keywords: | Cyclomaltoheptaoses β-Cyclodextrin mono-2-O-modified O-Permethylcyclodextrin Selective modification |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|