Sensitization to stress: the enduring effects of prior stress on amphetamine-induced rotational behavior |
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| Authors: | T E Robinson A L Angus J B Becker |
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| Affiliation: | Department of Psychology and Neuroscience Laboratory Building The University of Michigan 1103 E. Huron St., Ann Arbor, MI 48104-1687, USA |
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| Abstract: | In rats with a unilateral 6-OHDA lesion of the substantia nigra exposure to footshock or immobilization stress produced a long-lasting enhancement in the rotational behavior evoked by a subsequent injection of amphetamine. However, the effect was dependent on the environmental context in which stress was applied. It is suggested that stress may induce enduring changes in brain and behavior similar to those produced by psychomotor stimulant drugs. |
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