A graphical user interface for BIOEQS: a program for simulating and analyzing complex biomolecular interactions |
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| Authors: | Rosales Tilman Royer Catherine A |
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| Institution: | a Laboratory of Molecular Biophysics, Optical Spectroscopy Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
b INSERM, U554, Université Montpellier 1, CNRS UMR5048, Montpellier 34090, France |
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| Abstract: | BIOEQS is a global analysis and simulation program for complex biomolecular interaction data developed during the 1990s. Its continued usefulness derives from the fact that it is based on a numerical solver for complex coupled biological equilibria rather than on closed-form analytical equations for the binding isotherms. Therefore, it is quite versatile, allowing easy testing of multiple binding models and analysis of systems too complex for closed-form solutions. However, a major drawback to a generalized use of this program has been the lack of a graphical user interface (GUI) for setting up the binding models and experimental conditions as well as for visualizing the results. We present here a new GUI for BIOEQS that should be useful in both research and teaching applications. |
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