A(beta) generation in autophagic vacuoles |
| |
| Authors: | Mizushima Noboru |
| |
| Institution: | Department of Bioregulation and Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo 113-8613, Japan. nmizu@rinshoken.or.jp |
| |
| Abstract: | Alzheimer's disease (AD) is the most common form of dementia among older people. It is characterized by the extracellular accumulation of beta-amyloid (Abeta) deposits called senile or neuritic plaques. Abeta is generated by the proteolytic cleavage of Abeta precursor protein (APP) by beta and gamma-secretases localized in the secretory and endocytic compartments. In this issue, Yu et al. (on p. 87) report a novel mechanism for the generation of Abeta peptides, which takes place in autophagic vacuoles (AVs) that accumulate in AD brains. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
